Prion protein ( PrP ) expression differences in microglia and astroglia influence 1 scrapie - induced neurodegeneration in retina and brain of transgenic mice
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چکیده
3 (Abbreviated: PrP expression and neurodegeneration in scrapie) 4 5 Lisa Kercher, Cynthia Favara, James F. Striebel, Rachel LaCasse, and Bruce Chesebro. 6 7 From the Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National 8 Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840. 9 10 Corresponding Author: Dr. Bruce Chesebro, Laboratory of Persistent Viral Diseases, Rocky 11 Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, 903 S. 4 th 12 Street, Hamilton, MT 59840. Email: [email protected] 13 14 8 Figures, Pages: 30 15 16
منابع مشابه
Prion protein expression differences in microglia and astroglia influence scrapie-induced neurodegeneration in the retina and brain of transgenic mice.
Activated microglia and astroglia are known to be involved in a variety of neurodegenerative diseases, including prion diseases. In the present experiments, we studied activation of astroglia and microglia after intraocular scrapie infection in transgenic mice expressing prion protein (PrP) in multiple cell types (tg7 mice) or in neurons only (tgNSE mice). In this model, scrapie infection and p...
متن کاملPrion protein ( PrP ) expression differences in microglia and astroglia influence
3 (Abbreviated: PrP expression and neurodegeneration in scrapie) 4 5 Lisa Kercher, Cynthia Favara, James F. Striebel, Rachel LaCasse, and Bruce Chesebro. 6 7 From the Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National 8 Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840. 9 10 Corresponding Author: Dr. Bruce Chesebro, Labor...
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